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Changsha Staherb Natural Ingredients Co., Ltd
Changsha Staherb Natural Ingredients Co., Ltd THE PROFESSIONAL SUPPLIER OF STANDARDIZED PLANT EXTRACT
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Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin

Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin

Brand Name : STAHERB
Model Number : STA-83
Certification : ISO,KOSHER
Place of Origin : China
MOQ : 1kg
Price : negotiation
Payment Terms : L/C, T/T, Western Union
Supply Ability : 100000kgs
Delivery Time : 5-8 working days
Packaging Details : 1kg/bag,25kg/drum
Specification : 80,98%
Active ingredients : 7-ethyl-10-hydroxycamptothecin
part : Tree Bark and Fruit
Extraction Type : Solvent Extraction
Application : medicals
Form : powder
cas : 86639-52-3
Appearance : light yellow
Test Method : HPLC
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What is 7-Ethyl-10-hydroxycamptothecin?

Herbal Extract Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Herbal Extract Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

It is widely believed that Herbal Extract Camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, Herbal Extract Camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, Herbal Extract Camptothecin ultimately causes cell death.
At present, some Camptothecin analogs, either semi-synthetic or synthetic drug based on Camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.


Product Name7-ethyl-10-hydroxycamptothecin
Other name4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Used PartLeaf
Active Ingredient7-ethyl-10-hydroxycamptothecin
Specs98% by HPLC
Particle Size100% pass through 80 mesh sieve
Heavy metals(as Pb)<10ppm
Arsenic(as AS2O3)<2ppm
Total bacterial countMax.1000cfu/g
Yeast & MouldMax.100cfu /g
Escherichia coli presenceNegative
SalmonellaNegative
Molecular FormulaC22H20N205
Molecular Weight392.40

Certificate of Analysis


AnalysisSpecificationResults
Assay(By HPLC)7-Ethyl-10-hydroxycamptothecin>98%98.56%
Chemical Control
IdentificationVerfied
Heavy metals<10ppmComplies
PesticidesNegativeNegative
Physical Control
AppearanceLight yellow crystalline powderComplies
ColorLight yellowComplies
OdorCharacteristicComplies
TasteCharacteristicComplies
Mesh Size100% through 80 meshComplies
Loss On Drying<5%2.50%
Microbiological
Total Plate Count<1000CFU/gmComplies
Yeast & Mold<100CFU/gmComplies
SalmonellaNegativeNegative
E.ColiNegativeNegative
StorageCool and Dry
Shelf life2 years

Function of 7-ethyl-10-Hydroxycamptothecin


1. 7-ethyl-10-Hydroxycamptothecin can make changes in skin epidermal keratinization process.


2. 7-ethyl-10-Hydroxycamptothecin can anti-cancer, anti-virus, anti early pregnancy.


3. 7-ethyl-10-Hydroxycamptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.


Application of 7-ethyl-10-Hydroxycamptothecin:


1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.


2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.


3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.


4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.


Packing:1kg/bag,25kg/drum
Lead time:5-8 workding days


Product Tags:

organic plant extracts

      

herbal plant extract

      
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Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Images

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